Dr. Katherine Siminovitch

Dr. Katherine Siminovitch is a rheumatologist who studies the molecular mechanisms underpinning development of immunodysregulatory disease. As a senior investigator at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Dr. Siminovitch aims to provide new knowledge and technologies enabling more efficacious and “individualized” therapies for immunological diseases.

Dr. Siminovitch’s research program is directed at identifying the molecular and cellular interactions which regulate normal immune responses and which, when disrupted, result in immune deficiency or autoimmune diseases such as rheumatoid arthritis and vasculitis. Using both basic research tools and clinical sample sets, Dr. Siminovitch focuses on defining the genetic lesions predisposing to these diseases and the molecular pathways which couple these lesions to immune cell dysfunction and disease.

Dr. Siminovitch is a Professor of Medicine at the University of Toronto and serves as the Director of the Fred A. Litwin Family Centre of Genetic Medicine at Mount Sinai Hospital and the University Health Network. She also directs the MSH/UHN Clinical Genomics Centre and a Centre of Excellence in Precision Medicine in Autoimmune Disease.

Dr. Siminovitch was awarded a Canada Research Chair in Immunogenomics and previously received a CIHR Senior Scientist Award, an Arthritis Society of Canada Research Scientist Award, an Ontario Ministry of Health Career Scientist Award and the Canadian Life and Health Association Medical Scholarship

She holds an MD from the University of Toronto and is a Fellow of the Royal College of Physicians and Surgeons of Canada in Internal Medicine and Rheumatology.